Description
The intention of this book is to review the latest developments in the understanding of acne and its treatment. The contents cover the molecular and cell biological aspects of sebocytes, sebaceous glands, and the pilosebaceous unit through to the pathogenesis of acne, its treatment with hormones, antimicrobials, retinoids, and laser. Novel actives are reviewed, such as the effect of octadecenedioic acid, sphingolipids, and enzyme inhibitors. Formulation principles and the importance of follicular delivery through sebum are overviewed and, finally, in vitro testing methods. This book is an invaluable resource for dermatologists as well as scientists working in the pharmaceutical and skin care industries. Each chapter reviews the most relevant literature and gives personal insight into tackling the problems associated with the treatment of acne, its underlying pathophysiology, and its therapy.
The book is a result of the contributions of experts in their own areas and is the work of an international team representing scientists from many disciplines. Dermatologists, cosmetic scientists, and researchers will find Acne and Its Therapy an invaluable and in-depth analysis of the pathogenesis of acne and its treatment.
Contents
PART I: THE BIOLOGY OF THE SEBACEOUS GLAND AND PATHOPHYSIOLOGY OF ACNE
1. Overview of the Pathogenesis of Acne
Guy F. Webster
2. Cell Biology of the Pilosebaceous Unit
Helen Knaggs
3. Sebum Secretion and Acne
Philip W. Wertz
4. The Molecular Biology of Retinoids and Their Receptors
Anthony V. Rawlings
5. Molecular Biology of Peroxisome Proliferator-Activated Receptors in Relation to Sebaceous Glands and Acne
Michaela M. T. Downie and Terence Kealey
6. Antimicrobial Peptides and Acne
Michael P. Philpott
PART II: ACNE TREATMENTS
7. Hormonal Influences in Acne
Diane Thiboutot
8. Antimicrobial Therapy in Acne
Guy F. Webster
9. Topical Retinoids
Daniela Kroshinsky and Alan R. Shalita
10. Phototherapy and Laser Therapy of Acne
Guy F. Webster
11. Benzoyl Peroxide and Salicylic Acid Therapy
Gabi Gross
12. Treating Acne with Octadecenedioic Acid: Mechanism of Action, Skin Delivery, and Clinical Results
Johann W. Wiechers, Anthony V. Rawlings, Nigel Lindner, and William J. Cunliffe
13. The Effect of Sphingolipids as a New Therapeutic Option for Acne Treatment
Saskia K. Klee, Mike Farwick, and Peter Lersch
14. 5a-Reductase and Its Inhibitors
Rainer Voegeli, Christos C. Zouboulis, Peter Elsner, and Thomas Schreier
PART III: ACTIVE DELIVERY, FORMULATION, AND TESTING
15. Sebum: Physical–Chemical Properties, Macromolecular Structure, and Effects of Ingredients
Linda D. Rhein, Joel L. Zatz, and Monica R. Motwani
16. Targeted Delivery of Actives from Topical Treatment Products to the Pilosebaceous Unit
Linda D. Rhein, Joel L. Zatz, and Monica R. Motwani
17. Topical Therapy and Formulation Principles
Steve Boothroyd
18. In Vitro Models for the Evaluation of Anti-acne Technologies
John Bajor