Description
Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and material sciences (i.e., nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. The goal of this book is to draw attention to the critical role that the pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral Fellows, researchers new to the field of regenerative medicine and its companion field, tissue engineering, as well as experienced investigators looking for new research avenues. This is the first state-of-the-art book in this rapidly evolving field of research.
Contents
Section I: Basic Principles of Regenerative Pharmacology
1. Introduction to Regenerative Pharmacology: A Short Primer on the Role of Pharmacological Sciences in Regenerative Medicine 3
george j. christ and karl-erik andersson
2. Regenerative Pharmacology of the Bladder 15
david burmeister, karl-erik andersson, and george j. christ
3. Mechanical Control of Adult Mesenchymal Stem Cells in Cardiac Applications 34
peter a. galie and jan p. stegemann
4. Kidney and Bladder Regeneration: Pharmacologic Methods 52
timothy a. bertram, belinda j. wagner, and bert spilker
Section II: Enabling Technologies for Regenerative Pharmacology
5. Stem and Progenitor Cells in Regenerative Pharmacology 75
mark e. furth, martin k. childers, and lola m. reid
6. Micro- and Nanoscale Delivery of Therapeutic Agents for Regenerative Therapy 127
justin m. saul and benjamin s. harrison
7. Bioreactor Technologies for Tissue Engineering a Replacement Heart Valve 157
stefanie biechler, michael j. yost, richard l. goodwin, and jay d. potts
8. Incorporation of Active Factors (Pharmacological Substances) in Biomaterials for Tissue Engineering 167
roche de guzman and mark van dyke
9. Enabling Drug Discovery Technologies for Regenerative Pharmacology 190
g. sitta sittampalam
10. Animal Models of Regenerative Medicine 219
j. koudy williams, james yoo, and anthony atala
Section III: Future Applications of Regenerative Pharmacology
11. Gap Junction–Mediated Therapies to Eliminate Cardiac Arrhythmias 237
peter r. brink, virginijus valiunas, and ira s. cohen
12. Regenerative Cardiac Pharmacology: Translating Stem Cell Biology into Therapeutic Solutions 252
atta behfar and andre terzic
13. Wound Healing and Cell Therapy for Muscle Repair 270
j.b. vella and johnny huard
14. Regenerative Pharmacology of Implanted Materials and Tissue-Engineered Constructs 290
emily ongstad, michael j. yost, richard l. goodwin, harold i. friedman, stephen a. fann, gautam s. ghatnekar, and robert g. gourdie
15. The Past, Present, and Future of Tissue Regeneration 311
m. natalia vergara and panagiotis a. tsonis