Description
The first edition of this Handbook appeared four years ago and seems to have been useful, so this update, based on the 6 th edition of Brook’s Clinical Pediatric Endocrinology , follows a very similar format but with some notable additions.
Molecular biology has advanced rapidly in those years and is beginning to have a real clinical impact so considerable attention has been paid to this advance. You will also find clinical pitfalls highlighted and self-assessment challenges in each chapter. Where possible, we have included links to established guidelines and consensus views.
The enrolment of Professor Mehul Dattani as co- editor has been a great comfort to his (literally) senior colleague and it is my hope that you will profit as much from his extraordinary grasp of the science and practice of clinical pediatric endocrinology as I have. As always, we should be very glad to have errors drawn to our attention.
The team at Wiley-Blackwell, Oliver Walters, Jenny Seward, Rob Blundell and Helen Harvey, provides as smooth an operation as an author could wish for; we are very grateful for their help in producing this book. We hope that you will enjoy it.
Charles Brook
Mehul Dattani
2012
Contents
Preface , vii
List of Abbreviations, ix
1 The Relevance of Molecular Biology to Clinical Practice , 1
2 Hormones: their Nature, Actionand Measurement , 15
3 The Hypothalamo-Pituitary Axis , 31
4 Endocrine Problems of Infancy , 48
5 The Management of Growth Disorders , 70
6 The Management of Puberty Disorders , 99
7 The Thyroid Gland , 129
8 The Adrenal Gland , 151
9 Disorders of Calcium and Bone Metabolism , 175
10 Water Balance , 210
11 Hypoglycemia, 230
12 Obesity and Type 2 Diabetes Mellitus , 248
13 Type 1 Diabetes Mellitus , 267
14 Endocrine Neoplasia, 296
15 Tests and Normal Values in Pediatric Endocrinology , 309
Appendix 1: Syndrome-Specifi c Growth Charts , 325
Appendix 2: Normal Values , 337
Index, 343