The success of our first edition, with reader feedback, has encouraged us to produce an expanded and updated second edition of Bioanalytical Chemistry. Over the past decade, we have both read, in the primary literature, about enormous advances in certain areas, including imaging and microﬂuidic devices. It had also been suggested that an introductory chapter involving instrumental measurement principles and methods would be helpful to readers. New chapters were warranted, and we have included these in our second edition.
Traditional areas of bioanalytical chemistry, such as electrophoresis, chromatographyand immunoassay, have also seen surprising and significant developments. An enormous development in 2D electrophoresis, involving the simultaneous separation of two or more cell lysates on a single gel, has provided a quantum leap for proteomic studies. Nanoparticles, quantum dots and new polymers have seen many applications to biomolecule separation and quantitation. We have attempted to provide an introduction, as well as leading references, to these areas in our second edition.
The Argentine-Canadian collaboration of the authors began in the mid-1990s as a result of mutual interests in bioanalytical chemistry research and teaching. Over the years, despite the advantages of modern telecommunications technology, we have found that travel is both necessary and beneﬁcial, especially when the ﬁnal stages of manuscript preparation are underway. With the north-south travel, we have found that the climate is always pleasant somewhere.
SUSAN R. MIKKELSEN EDUARDO CORTÓN Buenos Aires, Argentina