Now in its second edition, Basic Medical Biochemistry continues to provide a unique clinically based approach to the subject that is perfect for medical students. The authors use patient vignettes throughout the book to emphasize the importance of biochemistry to medicine, delivering a text that is specifically oriented toward clinical application and understanding.
Patients have unique and humorous names that serve as mnemonics to help students remember the vignettes. Facts and pathways are also emphasized, showing how the underlying biochemistry is related to the body’s overall physiologic functions. The result is a clear, comprehensive, and easy-to-read text that helps medical students understand the allimportant role the patient plays in the study of biochemistry.
Other features and highlights include:
- A new back-of-book CD offers 9 animations on biochemical topics (oxidative phosphorylation, DNA replication, DNA mutation, protein synthesis, PCR, TCA cycle) as well as patient “files,” disease links, and over 200 additional review questions not found in the book.
- A well-organized icon system quickly guides you to the information you need.
- Marginal notes provide brief clinical correlations, short questions and answers, and interesting asides.
- Each chapter ends with “Biochemical Comments” and “Clinical Comments”; both sections summarize the key biochemical and clinical concepts presented in the chapter.
- USMLE-style questions at the end of each chapter help students review for course or board exams.
- Two-color art program includes illustrations of chemical structures and biochemical pathways as well as conceptual diagrams.
- A new section on tissue metabolism has been added that summarizes common clinical problems such as liver disease and alcoholism.
To learn biochemistry in the context of clinical problems, you won’t find a better resource than Basic Medical Biochemistry.
Table of Contents
Section One: Fuel Metabolism
Chapter 1: Metabolic Fuels and Dietary Components
Chapter 2: The Fed or Absorptive State
Chapter 3: Fasting
Section Two: Chemical and Biological Foundations of Biochemistry
Chapter 4: Water, Acids, Bases, and Buffers
Chapter 5: Structures of the Major Compounds of the Body
Chapter 6: Amino Acids in Proteins
Chapter 7: Structure-Function Relationships in Proteins
Chapter 8: Enzymes as Catalysts
Chapter 9: Regulation of Enzymes
Chapter 10: Relationship between Cell Biology and Biochemistry
Chapter 11: Cell Signaling by Chemical Messengers
Section Three: Gene Expression and Protein Synthesis
Chapter 12: Structure of the Nucleic Acids
Chapter 13: Synthesis of DNA
Chapter 14: Transcription: Synthesis of RNA
Chapter 15: Translation: Synthesis of Proteins
Chapter 16: Regulation of Gene Expression
Chapter 17: Use of Recombinant DNA Techniques in Medicine
Chapter 18: The Molecular Biology of Cancer
Section Four: Oxidative Metabolism and the Generation of ATP
Chapter 19: Cellular Bioenergetics: ATP and O2
Chapter 20: Tricarboxylic Acid Cycle
Chapter 21: Oxidative Phosphorylation and Mitochondrial Function
Chapter 22: Generation of ATP from Glucose: Glycosis
Chapter 23: Oxidation of Fatty Acids and Ketone Bodies
Chapter 24: Oxygen Toxicity and Free Radical Damage
Chapter 25: Metabolism of Ethanol
Section Five: Carbohydrate Metabolism
Chapter 26: Basic Concepts in the Regulation of Fuel Metabolism by Insulin, Glucagon, and Other Hormones
Chapter 27: Digestion, Absorption, and Transport of Carbohydrates
Chapter 28: Formation and Degradation of Glycogen
Chapter 29: Pathways of Sugar Metabolism: Pentose Phosphate Pathway, Fructose, and Galactose Metabolism
Chapter 30: Synthesis of Glycosides, Lactose, Glycoproteins, and Glycolipids
Chapter 31: Gluconeogenesis and Maintenance of Blood Glucose Levels
Section Six: Lipid Metabolism
Chapter 32: Digestion and Transport of Dietary Lipids
Chapter 33: Synthesis of Fatty Acids, Triacylglycerols, and the Major Membrane Lipids
Chapter 34: Cholesterol Absorption, Synthesis, Metabolism, and Fate
Chapter 35: Metabolism of the Eicosanoids
Chapter 36: Integration of Carbohydrate and Lipid Metabolism
Section Seven: Nitrogen Metabolism
Chapter 37: Protein Digestion and Amino Acid Absorption
Chapter 38: Fate of Amino Acid Nitrogen: Urea Cycle
Chapter 39: Synthesis and Degradation of Amino Acids
Chapter 40: Tetrahydrofolate, Vitamin B12, and S-Adenosylmethionine
Chapter 41: Purine and Pyrimidine Metabolism
Chapter 42: Intertissue Relationships in the Metabolism of Amino Acids
Section Eight: Tissue Metabolism
Chapter 43: Actions of Hormones Regulating Fuel Metabolism
Chapter 44: The Biochemistry of the Erythrocyte and Other Blood Cells
Chapter 45: Blood Plasma Proteins, Coagulation and Fibrinolysis
Chapter 46: Liver Metabolism
Chapter 47: Metabolism of Muscle at Rest and During Exercise
Chapter 48: Metabolism of the Nervous System
Chapter 49: The Extracellular Matrix and Connective Tissue